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Brain infection starts in gut, study finds


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Brain infection starts in gut, study finds

 

Date: 10/08/2015


The study reveals how the proteins - called prions - spread from the gut to the brain after a person or animal has eaten contaminated meat.

Scientists say their findings could aid the earlier diagnosis of prion diseases - which include variant Creutzfeldt-Jakob disease (vCJD) in people and bovine spongiform encephalopathy (BSE) in cows.

In people, the disease remains very rare - 229 people have died from vCJD since it was first identified almost 20 years ago, of which 177 were from the UK.

"Whether all individuals with evidence of prion infection in their gut go on to develop neurological disease is not known. We need a greater understanding of what factors enhance our susceptibility to prion diseases so that we can put in place safeguards to prevent these conditions from spreading in people and farmed animals."  Professor Neil Mabbott, The Roslin Institute, University of Edinburgh
 
Prions are infectious proteins with abnormal shapes that can be passed between people and animals by eating contaminated meat.

Until now, it was not known how prions spread from the gut to the brain after consuming infected meat.

Researchers at University of Edinburgh’s Roslin Institute studied the course of prion infection in mice.

They found that prions must first build up in specialised structures in the lining of the small intestine before they are able to spread throughout the body to the brain.

The structures - called Peyer’s patches - are part of the body’s immune system and form the first line of defence against contaminated food.

The study suggests prions hijack Peyer’s patches to cause infection.

Prions did not build up in similar patches in the large intestine until a later stage of infection, the team found.

At this stage, prions were also detected in the spleen and lymph nodes.


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Source: Roslin Biocentre

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