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RESTORATION a 4-year collaborative European research project aiming to develop new resorbable ceramic biocomposites for orthopaedic and maxillofacial applications is now complete. The project partners are very pleased with the outcomes which demonstrate great future potential.
With a cross-functional approach, expert knowledge of areas including materials science, mechanical response, processing, clinical delivery and biological interaction was combined and led to exciting developments such as new resorbable ceramic biocomposites.
The RESTORATION project aimed to develop resorbable bioceramic composite materials for three main applications:
Osteoarthritis: developing functionally gradient bioceramic composite plugs for osteochondral applications.
Vertebroplasty and Kyphoplasty: a new generation of vertebral cements with appropriate biological, mechanical and rheological properties are being developed.
Maxillofacial Fracture Fixation: developing new bioceramic composites, which will possess sufficient stiffness and strength to protect and support the broken bone.
As a result of the four-year project, new resorbable ceramic biocomposites for orthopaedic and maxillofacial applications have been developed. The products can mimic the structure of bones and can be designed to closely match the mechanical requirements of the implant sites. In addition, some of the bioceramics are bioactive, which means they can be fully absorbed by the body.
Orla’s role was to develop proteins to enhance the bioactivity of the resorbable materials. These novel engineered proteins were used to protein coat the ceramic implants for use in the knee, for repair of cartilage damaged by osteoarthritis.
Various motifs and domains from biologically active ECM components were engineered into the Orla surface-binding unit (SBU). The SBU is able to bind to glass and enhanced the display of the introduced sequences. Coating glass surfaces with Orla proteins improved the attachment of rat bone marrow stroma cells and several of the proteins were able to significantly increase the differentiation of the cells towards the osteoblast lineage. This providing another example of the power of Orla’s protein engineering platform and its broad application across many areas of Life Sciences.
RESTORATION project involved over a 4-year period recognised organisations from all over Europe: Newcastle University (project coordinator – UK), JRI Orthopaedics (UK), Sagetis Biotech (ES), Universidade de Évora (PT), Orla Protein Technologies (UK), LEITAT (ES), Karolinska Institutet (SE), Bionica Tech /Corep (IT), Institut Quimic de Sarria (ES), Glass Technology Services (UK), and FPO (IT).
More information on http://restoration-project.eu or watch the project video https://vimeo.com/157420641
This project has received funding from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No 280575.