Parsortix Gaining Traction at Prestigious EACR Conference
New data from key opinion leaders on research undertaken with the Parsortix system highlights increasing use and broad potential applications
ANGLE plc, the specialist medtech company, is pleased to announce that significant profile was achieved for ANGLE’s Parsortix system at EACR 2016 (the European Association for Cancer Research Biennial Meeting) held in Manchester 9 to 12 July 2016.
Importantly, performance of the system was referenced in two keynote presentations by independent investigators, Caroline Dive of Cancer Research UK Manchester Institute and Klaus Pantel of University Medical Centre Hamburg-Eppendorf (UKE) respectively.
There were three separate scientific poster presentations on Parsortix accepted for presentation at the conference as follows:
- Fraunhofer ITEM (Institute for Toxicology and Experimental Medicine) Regensburg, Germany: Surface marker independent enrichment of circulating or disseminated cancer cells from blood or lymph nodes using a microfluidic device
- Cancer Research UK Manchester Institute: Combined circulating tumour cell (CTC) and circulating tumor DNA (ctDNA) analysis of blood from patients with pancreatic cancer
- ANGLE in-house: A highly sensitive method for circulating tumour cell antigen quantification in liquid biopsy
The published poster presentations will be uploaded to http://www.angleplc.com/the-parsortix-system/download-files/ once available.
The published poster presentations add to the growing published evidence in support of the use of ANGLE’s Parsortix system to easily and effectively harvest cancer cells from the blood of patients for analysis.
Key points in the published posters include:
- Fraunhofer ITEM’s findings in relation to lymph node cell analysis are potentially commercially highly relevant as their work identifies and demonstrates feasibility in a new market for Parsortix working with lymph node cell suspensions rather than patient blood. Primary cancers often spread initially via the lymph node network. The work undertaken was in melanoma where assessment of lymph nodes is “important for determining staging and treatment of melanoma patients”. This is the first time results have been published relating to the use of Parsortix with the melanoma cancer type. Lymph node cell analysis is also applicable more generally, for example, in breast cancer a key issue at presentation is whether the cancer has spread from the breast to the lymph nodes. Fraunhofer ITEM’s work suggests that the Parsortix system may facilitate analysis of the lymph nodes to determine whether cancer is present or not. This is an area ANGLE has not previously investigated. Fraunhofer ITEM are a research use customer and their work is entirely instigated, directed, funded and executed by them, independent of ANGLE.
- Cancer Research UK Manchester Institute’s poster presents important work demonstrating a working protocol using a single patient blood sample for ctDNA and CTC analysis using Parsortix. This enables researchers already working with ctDNA to additionally adopt Parsortix CTC analysis with the same blood sample allowing complementary and/or additional information to be obtained from CTCs. Furthermore, it shows the capability of Parsortix to work with pancreatic cancer, which has not previously been demonstrated, and that the CTCs harvested can be subjected to DNA analysis for a key mutation KRAS. The technique used was ddPCR (digital droplet PCR). This may have wide applicability once optimised for the Parsortix harvested CTCs.
- ANGLE’s own poster demonstrated working protocols for determining the level of specific protein cell surface markers on the CTCs harvested by Parsortix. This is particularly relevant as proteins cannot be assessed using ctDNA. The two protein cell surface markers demonstrated were ErbR2 and gp100. These are notable as they are key to the actions of breast cancer and melanoma respectively and are specific targets for drugs under development. Identification of these protein cell surface markers on CTCs may be an indication of patient response to specific drugs in the future. This would allow patients to have a blood test ahead of receiving a particular drug to determine whether the drug is likely to be effective in their particular case. Consequently, the results presented will assist ANGLE in dialogue with pharmaceutical, biotech and immunotherapy companies about adoption of the Parsortix system for research use in drug trials.
ANGLE Founder and Chief Executive, Andrew Newland, commented:
“These presentations further highlight that Parsortix is extremely flexible and versatile and that its use is building. At EACR, one of the leading European cancer conferences, we have seen customers develop completely novel potential applications for Parsortix; as well as demonstration of use in additional cancer types and the potential for patient drug response to be assessed. In summary, these presentations further highlight the potential market opportunity and key role Parsortix has to play in the fast growing, liquid biopsy space, a rapidly growing market segment for cancer diagnosis and management.”