Protein engineering for the improved display of target proteins


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Protein engineering for the improved display of target proteins



Orla will present its protein engineering technology for immobilising proteins on surfaces on a poster at the Recombinant Protein Technology 2016 conference on 8th and 9th June in Gothenburg, Sweden.

The two-day conference focuses on the latest advances in technologies for the design and production of recombinant proteins used in drug discovery. Top academics and industry representatives will come together to discuss innovations and solutions to meet future demand.

While current methods for displaying proteins and peptides on surfaces often result in poor orientation and structure, Orla uses a protein engineering approach to maximise the utility of protein or peptide-coated surfaces by controlling the structure and orientation of the target protein on the surface.

The flexibility of OrlaSURF allows the engineering of proteins and peptides into Orla’s anchoring protein in the optimal way resulting in better results. Comparison data presented include the improved detection of Ab binding through controlling the distance of displayed antigens from the surface. Additionally, data of improved results for target binding on various platforms and other comparison data will be presented.

Uniquely, the engineered molecules can be used across platforms and applications – opening up opportunities for improved analytics and increased efficiency. Once the fusion protein is created it can be used without further modification on commonly used analytical biosensor platforms (e.g. SPR, QCM), microtitre plates, polybeads and other affinity chromatography matrices.

Read the whole abstract of the poster on

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