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New research has identified the mechanisms that trigger disruption in the brain’s communication channels, linked to symptoms in psychiatric disorders including schizophrenia.
The study from the University of Bristol published in the Proceedings of National Academy of Sciences, could have important implications for treating symptoms of brain disorders.
Many of our everyday cognitive functions such as learning and memory rely on normal communication between the two regions of the brain – the hippocampus and prefrontal cortex. While previous studies have identified disruption to communication channels in these two areas of the brain contribute to symptoms in psychiatric disorders, the mechanisms that lead to these disturbances have been largely unknown, until now.
In this study supported by BBSRC and the Wellcome Trust, the researchers studied neurotransmitters, called glutamate and dopamine, which work together in controlling normal transmission between these brain regions by communicating chemical information throughout our brain and are disrupted in schizophrenics.
The team found that subtle changes in the interplay of these transmitters completely altered the flow of information from the hippocampus to prefrontal cortex. Over-activation of the D2 class of dopamine receptors led to suppression of the function of NMDA receptors, which are activated by the neurotransmitter glutamate, at the synaptic connection between hippocampus and prefrontal cortex. This in turn leads to a marked disruption of communication between these brain regions.For more click here